However, ATTR amyloidosis, in particular, can be easily diagnosed using a simple skeletal scintigraphy. Although it is still unclear by which mechanism the bone-specific tracers (e.g. DPD) attach to the amyloid in the heart, the skeletal scintigraphy shows a positive predictive value of 100% here (with AL amloidosis excluded at the same time, i.e. negative serum and urine Electrophoresis; Gillmore et al. Circulation. 2016 Jun 14; 133 (24): 2404-12) for the diagnosis of ATTR amyloidosis (Figure 5). There are no special preparations required for this diagnotic procedure.
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