Research Group Prof. Dr. med. Nicole Ochsenbein-Kölble

Main Field of Research, Abstract

The main focus of the group is on physiological and pathophysiological aspects of fetal membranes. Preterm premature rupture of membranes occurs in approximately 1% of all pregnancies and is associated with 30-40% of preterm deliveries. Thus, a major goal is to develop sealing and healing methods for this important problem in obstetrics. Current research projects include mechanical aspects, normal growth, changes near term, genetic polymorphism and healing and sealing with suitable techniques.

Main Fields of Research, Keywords

PPROM, fetal membranes, premature labor, premature delivery, amniopatch, amniograft

Special Techniques and Equipment

Tissue engineering, cell biology, RNA preparation, real time PCR, electrophoresis, immune histochemistry, FACS, electron microscopy

Education and Training

Seminars in fetal-maternal medicine


Emdo Stiftung, University of Zurich


Michaela Kolbe, PD Dr. rer. nat.

Leiterin Simulationszentrum

Tel. +41 44 255 16 95
Spezialgebiete: Simulations-basierte Trainings, Debriefings, Speaking Up, schwierige Gespräch, Safety Management, Wissenschaftliche Studien über und mit Teams und Simulation

Group Members

  • Mari GC, Deter RL, Carpenter R, Rahman F, Zimmermann R, Moise K, et al. Noninvasive diagnosis by doppler ultrasonography of fetal anemia due to maternal alloimmunization. N Engl J Med 2000; 342:9-14.
  • Kurmanavicius J, Streicher A, Wright EM, Wisser J, Müller R, Royston Zimmermann R. Reference values of fetal peak systolik blood flow velocity in the middle cerebral artery at 19-40 weeks of gestation. Ultrasound Obstet Gynecol 2001;17:50-53.
  • Ochsenbein-Imhof N, Huch A, Huch R, Zimmermann R. No benefit from post-caesarean wound drainage. Swiss Med Wkly 2001;131:246-250.
  • Thaler E, Huch R, Huch A, Zimmermann R. Compression tights prophylaxis of emergent varicose veins in pregnancy: a prospective randomised controlled study. Swiss Medical Weekly 2001;131:659-662.
  • Wegmann B, Huch R, Huch A, Zimmermann R. Schwangerschaftsultraschall in der Schweiz – Eine repräsentative nationale Erhebung. Gynäkol Geburtshilfliche Rundsch 2001;41:32.
  • Zimmermann R, Durig P, Carpenter RJJ, Mari G. Longitudinal measurement of peak systolic velocity in the fetal middle cerebral artery for monitoring pregnancies complicated by red-cell alloimmunization – a prospective multi-center trial with intention to treat. BJOG 2002;109:746-752.
  • Ochsenbein-Kölble N, Bilic G, Hall H, Huch R, Zimmermann R. Inducing proliferation of human amnion epithelial and mesenchymal cells for prospective engineering of membrane repair. J Perinat Med 2003;accepted.
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