Research studies show that the immune system can influence the development and progression of cancer. The use and manipulation of the immune system is therefore a promising therapeutic option to fight cancer. Physicians and scientists of the CCCZ Research Area Tumor Immunology investigate the interaction between the tumor and immune system. The overall aim is to develop novel immunotherapies with minimal side effects.
Cancer Research Areas & Groups
CCCZ integrates and supports all cancer research activities of the UZH, USZ, Balgrist University Hospital and the University Children's Hospital Zurich.
Dedicated research areas have been established for Tumor Immunology, (Epi)Genetics & Genomics, Oncogenic Signaling and Imaging, Technology Development and Digitalization. In these areas, scientists and physicians from more than 60 research groups and clinical departments work closely together to facilitate the translation of scientific discoveries into clinical application. The overall aim is to integrate basic research into translational and clinical concepts towards precision oncology.
CCCZ Cancer Research Areas
Many of the characteristics of cancer cells, such as malignant growth and the ability to metastasize, are influenced by (epi)genetic and genomic changes. Research groups of the CCCZ Epigenetics, Genetics and Genomics Research Area study various aspects of gene alterations in cancer aiming to develop targeted treatment concepts.
Signal transduction pathways within and between cells are often deregulated in cancer and contribute to uncontrolled growth and metastasis. In the CCCZ Research Area Oncogenic Signaling, scientists and physician investigate the effect of cancer drugs at the molecular level. Another focus of the program is to overcome drug resistance of cancer cells.
The CCCZ Research Area for Imaging, Technology Development and Digitization pursues the goal of developing personalized diagnosis and treatment methods for cancer. Novel imaging techniques such as innovative MRI sequences and PET imaging as well as radiomics enable more precise characterization of cancer. High-throughput molecular methods like sequencing, proteomics, metabolomics and imaging are essential for molecular diagnostics and monitoring of disease progression. For the analysis of scientific and clinical data, the development of modern bioinformatics and information technologies are of central importance.
CCCZ Research Groups A-Z
- Isabelle Arnold, Prof. Dr., Mucosal Immunology
- Matthias Altmeyer, Prof. Dr., Genome instability in cancer and aging
- Konrad Basler, Prof. Dr., WNT and hedgehog signalling in colorectal cancer
- Martin Baumgartner, Prof. Dr., Pediatric molecular neuro-oncology research
- Burkhard Becher, Prof. Dr., Inflammation Research
- Felix Beuschlein, Prof. Dr. med.,Department of Endocrinology, Diabetology and Clinical Nutrition
- Bernd Bodenmiller, Prof. Dr., Quantitative Biology
- Beat Bornhauser, Prof. Dr., Cell death and leukemia
- Lubor Borsig, Prof. Dr., Borsig Group
- Jean-Pierre Bourquin, Prof. Dr. med., Pediatric Onoclogy
- Onur Boyman, Prof. Dr. med., Boyman Group
- Maries van den Broek, Prof. Dr., Tumor Immunology
- Amedeo Caflisch, Prof. Dr., Caflisch Group
- Richard Chahwan, Prof. Dr., Cancer Immunobiology Lab
- Pierre-Alain Clavien, Prof. Dr. med.,Visceral and Transplantation Surgery
- Jacob Corn, Prof. Dr., Corn Lab
- Michael Detmar, Prof. Dr., Pharmacogenomics
- Raghvendra Dubey, Prof. Dr., Dubey Group
- Reinhard Dummer, Prof. Dr. med., Skin Cancer Clinical Research
- Daniel Eberli, Prof. Dr. Dr. med., Eberli Group
- Urs Greber, Prof. Dr., Greber Group
- Melanie Greter, Prof. Dr., Research Group
- Matthias Guckenberger, Prof. Dr. med., Radiomics Research Group
- Ana Guerreiro Stücklin, MD PhD, Translational Brain Tumor Research
- Alex Hajnal, Prof. Dr., Hajnal Lab
- Jürg Hodler, Prof. Dr. med., Diagnostic and Interventional Radiology
- Jason Holland, Prof. Dr., Radiochemistry and imaging science
- Michael Hottiger, Prof. Dr., Cell signalling in inflammatory associated diseases
- Pavel Janscak, Prof. Dr., Mechanism of DNA repair
- Michael Krauthammer, Prof. Dr., Clinical Data Science and Translational Bioinformatics Group
- Kuno Lehmann, Prof. Dr. med., Abdominal Surgical Oncology Group
- Mitch Levesque, Prof. Dr., Translational Dermato-Oncology
- Massimo Lopes, Prof. Dr.,Replication stress in cancer onset and therapy
- Markus Manz, Prof. Dr. med., Experimental Hematology
- Giancarlo Marra, Prof. Dr., Colorectal tumorigenesis
- Holger Moch, Prof. Dr. med., Urogenital cancer translational research
- Anne Müller, Prof. Dr.,Immunobiology of bacterial infection and cancer
- Christian Münz, Prof. Dr., Viral Immunobiology
- Hanspeter Nägeli, Prof. Dr., DNA repair, histone modifiers, chromatin remodelers
- Cesar Nombela-Arrieta, Prof. Dr., Microenvironmental Regulation of Hematopoiesis
- Chantal Pauli, Prof. Dr. med., Pauli Group
- Lorenza Penengo, Prof. Dr., Ubiquitin – Based Regulation of Genome Stability
- Andreas Plückthun, Prof. Dr., Protein engineering
- Martin Pruschy, Prof. Dr., Laboratory for applied radiobiology
- Gunnar Rätsch, Prof. Dr., Biomedical Informatics Group
- Luca Regli, Prof. Dr. med., Neurosurgery
- Gerhard Rogler, Prof. Dr. med, Gastroenterology and Hepatology
- Patrick Roth, Prof. Dr., Immunocure
- Raffaella Santoro, Prof. Dr., Santoro Group
- Alessandro Sartori, Prof. Dr., DNA Damage and Repair
- Beat Schäfer, Prof. Dr., Pediatric Onoclogy
- Michael Scharl, Prof. Dr. med., Translational Microbiome Research Center
- Roger Schibli, Prof. Dr., Radiopharmaceutical Sciences
- Isabelle Schmitt-Opitz, Prof. Dr. med., Department of Thoracic Surgery
- Gerald Schwank, Prof. Dr., Translational Genome Editing
- Lukas Sommer, Prof. Dr., Stem Cell Biology
- Christian Stockmann, Prof. Dr., Immunity, Angiogenesis and Tissue Remodeling
- Manuel Stucki, Prof. Dr., Genome Instability and Cancer
- Didier Surdez, Prof. Dr. Bone Sarcoma Research Laboratory
- Achim Weber, Prof. Dr. med., Weber Lab
- Michael Weller, Prof. Dr. med., Neurology
- Sabine Werner, Prof. Dr., Tissue repair and cancer
- Lynn Wong, Prof. Dr., Cell Death and regulation of Inflammation
- Thorsten Zenz, Prof. Dr. med., Lymphoma Research